|
Consensus recommendations |
Grade |
|
In people with renal impairment, including those with ESRD requiring dialysis no dose adjustment is required for:
|
A1 |
|
As ribavirin is renally excreted and cannot be removed by dialysis, if indicated in people with renal disease, it should be used with caution, and treatment should be supervised by a specialist experienced in the treatment of HCV and renal failure |
A1 |
|
If ribavirin is indicated in people with an eGFR OF 30-50 mL/min/1.73 m2, a low dose (e.g. alternating doses of 200 mg and 400 mg every other day) should be used, with close monitoring of haemoglobin levels. |
A1 |
|
If ribavirin is indicated in people with an eGFR < 30 mL/min/1.73 m2 or haemodialysis, a very low dose (e.g. 200 mg daily for patients not on haemodialysis; 200 mg pre-dialysis for patients on haemodialysis) should be used, with close monitoring of haemoglobin levels. |
A1 |