Regimens for chronic infection with genotypes 4 - 6 HCV

The combination of sofosbuvir plus velpatasvir is effective for the treatment of Gt 4–6 HCV.31 The combination of elbasvir plus grazoprevir with or without ribavirin is also PBS-listed for the treatment of Gt 4 HCV. The recommended treatment regimen is elbasvir plus grazoprevir for 12 weeks’ duration in people who are treatment-naive, as well as in people who have previously relapsed after treatment with pegIFN and ribavirin (Table 5).35,36,57 For people who have previously experienced on-treatment failure during pegIFN and ribavirin therapy (partial responders and non-responders), the recommended regimen is elbasvir plus grazoprevir plus ribavirin for 16 weeks’ duration.37 SVR rates ³95% were observed in Phase III studies using the recommended treatment regimens.35-37,57 

Tags: CCK