Perform a virological evaluation
Confirm the diagnosis of chronic HCV infection
In an individual who is repeatedly HCV antibody-positive, current HCV infection should be confirmed by a PCR assay for HCV RNA. Quantitative PCR is recommended as part of the pre-treatment assessment because HCV RNA level can identify people who are eligible for a short treatment duration with certain regimens.
Identify the genotype of HCV infection
Approved treatment regimens for HCV are genotype-specific, and the HCV genotype must be documented in the patient’s history to meet PBS criteria for the new HCV medicines. Therefore, HCV genotyping is necessary before treatment initiation. HCV genotyping is now a routine laboratory test.
Document the HCV treatment history
It is important to document any prior treatment for HCV infection. Key information includes treatment regimen, duration, adherence and response. These may influence the choice of treatment regimen and/ or treatment duration (see section on treatment for chronic HCV).