Post-treatment follow-up

Confirm SVR Successful viral eradication is defined as undetectable plasma HCV RNA using a highly sensitive PCR assay 12 weeks after completion of DAA therapy (SVR). This time point has shown excellent correlation with the previously used SVR24.61 Late relapse after SVR is very uncommon (< 0.5%), and the reappearance of HCV after this time point is most frequently due to reinfection. People who do not have cirrhosis and who have normal liver function test results after SVR (males, ALT < 30 U/L; females, ALT < 19 U/L) have no further need of specialist liver services and can be medically managed as if they never had HCV infection. There is no reason to repeat anti-HCV serological tests. It should be reiterated to all people who have achieved an SVR that persistence of anti-HCV antibodies is expected and that this does not represent active infection, nor does it confer immunity to reinfection. Those who fail to achieve an SVR should be assessed for explanations for treatment failure (especially adherence, drug resistance and reinfection). Retreatment should be considered as appropriate. In this setting, referral to an expert treatment centre is advisable.

Long-term management of liver disease Individuals whose liver function test results remain abnormal should be assessed by a specialist for alternative causes of liver disease (Table 6). All people with cirrhosis need to enter appropriate surveillance programs for HCC and oesophageal varices as recommended by existing guidelines.52-64 In addition, complications of chronic liver disease, including malnutrition and osteoporosis, should be addressed.

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