Methodology


This consensus statement presents a synthesis of evidence from the published literature and scientific abstract presentations available at the time of writing, relevant to the Australian PBS listing for HCV medications at the time of writing.

Levels of evidence for recommendations have been graded according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system.[133]

The quality of the evidence in the recommendations has been classified into one of three levels: high (A), moderate (B) or low (C).

The GRADE system offers two grades of recommendation: strong (1) or weak (2).

Evidence quality

Notes

Grade

High

Further research is very unlikely to change our confidence in the estimate of effect.

     A

Moderate

Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.

     B

Low

Further research is very likely to have an important impact on our confidence in the estimate and is likely to change the estimate. Any change of estimate is uncertain.

     C

Recommendation

Notes

Grade

Strong

Factors influencing the strength of the recommendation included the quality of the evidence, presumed patient-important outcomes and cost.

     1

Weak

Variability in preferences and values, or more uncertainty. Recommendation is made with less certainty, higher cost or higher resource consumption.

     2